There’s more to the quarantine flag, as it’s not binary on/off, and app translocation can trap even notarized applications if you don’t move them right.
first run
You unarchive a freshly downloaded app and try to give it a test run. It immediately crashes. Here’s one common reason, and how to solve it very simply.
Using Little Snitch, this becomes unresolvable, as the app can’t complete first run checks, and every time you try, it’s translocated to a different folder, causing Little Snitch to block it again.
The Eclectic Light Company 