At the start of the 15th century, Italian easel paintings used egg tempera. By the end, Leonardo da Vinci was pushing the technical boundaries using oil paint.
Colantonio
His time in Venice brought a succession of masterpieces, including the large San Cassiano altarpiece, a Salvator Mundi, and Virgin Annunciate which were highly influential.
Vasari claimed that he was trained by Jan van Eyck, but he probably learnt under an Italian artist in Milan before becoming the first Master in oils.
Did Antonello da Messina learn to paint with oils in Flanders, and bring back a revolution to Italy?
The Eclectic Light Company 